06:58 AM EDT, 03/26/2025 (MT Newswires) -- US benchmark equity indexes were trending downwards in Wednesday's premarket activity as geopolitical and tariff-related uncertainties continue to weigh on market sentiment.

Standard & Poor's 500 and the Dow Jones Industrial Average declined 0.1% each before the opening bell, while the Nasdaq was off 0.2%. Asian exchanges were mostly pointing higher while European bourses were tracking in the red midday on the continent.

Shares of GameStop ( GME ) jumped 14% pre-bell as the video game retailer disclosed plans to invest its capital in bitcoin and reported higher fiscal fourth-quarter earnings on a yearly basis. United Parcel Services (UPS) rebounded 0.4% after closing the previous session down 5.1%.

On the economic calendar, the weekly mortgage applications bulletin posts at 7 am ET, followed by the durable goods orders report for February at 8:30 am. The weekly EIA domestic petroleum inventories report is scheduled for a 10:30 am release, while the Atlanta Federal Reserve's Survey of Business Uncertainty report for the current month is out at 11 am.

Minneapolis Fed President Neel Kashkari is slated to speak at 10 am, while St. Louis Fed President Alberto Musalem speaks at 1:10 pm.

Cintas ( CTAS ) , Paychex ( PAYX ) , Dollar Tree ( DLTR ) , Chewy (CHWY), SailPoint (SAIL) and BRP (DOOO) report their latest financial results before the bell, among others. Jefferies Financial ( JEF ) , Alvotech ( ALVO ) , H. B. Fuller ( FUL ) and Petco Health and Wellness ( WOOF ) post earnings after markets close.

In premarket action, bitcoin edged up 0.2% to $88,243, West Texas Intermediate crude oil gained 0.7% to $69.45 a barrel, yields on 10-year Treasuries rose 2.6 basis points to 4.33% and gold nudged up 0.1% to $3,028 an ounce.