(Reuters) - U.S. stock indexes opened sharply lower on Wednesday as investors awaited details of U.S. President Donald Trump's tariffs to assess their impact on the global economy, corporate earnings and inflation.

The Dow Jones Industrial Average fell 342.35 points, or 0.82%, to 41,647.61, the S&P 500 fell 57.65 points, or 1.00%, to 5,577.02 and the Nasdaq Composite fell 241.23 points, or 1.38%, to 17,208.66.

(Reporting by Sruthi Shankar in Bengaluru; Editing by Anil D'Silva)