Major companies, particularly in Europe, could see billions of dollars in commercial deals canceled because of the US decision to reinstall sanctions on Iran, though the ultimate impact remains unclear due to the possibility of renegotiations and exemptions, experts say.

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President Donald Trump's decision to withdraw from the Iran nuclear deal and re-impose sanctions on Iran means companies worldwide must stop doing business with the country or run afoul of the US government.

Companies and countries with commercial deals with Iran would have either 90 or 180 days to wind down those activities, depending on the type of products being sanctioned. And firms would not be able to generate new business.

Certain exemptions and waivers can be negotiated, but the US did not say what products or countries might qualify.

Since the Iran nuclear deal was struck in 2015, it was mainly European companies that moved back in to strike deals with Iran, making Trump's decision particularly painful for the region.

"US Iran sanctions are hardly hitting any US companies, but aim primarily at European ones," Carl Bildt, the former leader of Sweden who is now co-chair of the European Council on Foreign Relations, said in a tweet. The EU has in the past found this utterly unacceptable, he added, though it was unclear still how European leaders would respond.

Among US companies, plane maker Boeing has signed the biggest deals, and US Treasury Secretary Steven Mnuchin said Tuesday that its existing licenses — as well as those of its European competitor, Airbus Group — would be invalidated.

In December 2016, Airbus signed a deal with Iran's national carrier, IranAir, to sell it 100 airplanes for around $19 billion at list prices. Boeing later struck its own deal with IranAir for 80 aircraft with a list price of some $17 billion, promising that deliveries would begin in 2017 and run until 2025. Boeing separately struck another 30-airplane deal with Iran's Aseman Airlines for $3 billion at list prices.

Boeing has yet to deliver any aircraft to Iran under those deals and said that it will "continue to follow the US government's lead."

Airbus, which is subject to the US license because it makes at least 10% of its aircraft components in the US, says it will abide by the new US sanctions but it could take "some time" to determine the full impact on the industry. It has already delivered two A330-200s and one A321 to Iran.

The US says the sanctions will also sharply curtail sales of oil by Iran, which is currently the world's fifth-largest oil producer. In the case of oil sales, there will be a 180-day period for countries to wrap-up existing contracts and achieve "significant reductions" in their purchases of crude from Iran.

Mnuchin declined to spell out what the administration would consider as a "significant reduction" in purchases of Iranian oil. US law gives the Treasury secretary the power to administer sanctions imposed by the president.

So far, French oil company Total SA has been the most aggressive Western oil company to move back into Iran, signing in July a $5 billion, 20-year agreement with Iran. A Chinese oil company also has a deal to develop the country's massive South Pars offshore natural gas field.

Total did not respond to requests for comment.

The price of oil rose sharply on Wednesday to its highest since 2014 on expectations that the new sanctions will crimp Iranian energy exports.

In other sectors, French carmaker PSA Peugeot Citroen reached a deal in 2016 to open a plant producing 200,000 vehicles annually in Iran. It said Wednesday that it is studying the implications of the US move and hopes the European Union will have a united position on the Iranian sanctions.

A group representing German trade interests said the US decision to withdraw from the Iran nuclear deal will hit German companies and urged the EU to protect their interests. Trade between Germany and Iran reached 3.4 billion euros ($4 billion) last year, according to BGA, another foreign trade association.

Mnuchin said the US's goal is to impose tough sanctions that will prompt Iran to re-negotiate the Iran nuclear deal.

"These sanctions do impact all the major industries (in Iran). They are very strong sanctions," Mnuchin said. "They worked last time. That is why Iran came to the table."